ABSTRACT
Background: Acute Kidney Injure (AKI) is a common complication associated with SARS-CoV2 infection. Sepsis, direct cellular injury due to the tropism of the virus, and systemic inflammation are mechanisms involved in its development. Methods: Prospective Cohort from March-2020 to March-2021 including 200 patients ≥18 yrs with SARS CoV2 for RT-PCR. All patients with development of AKI (KDIGO classification) during their hospitalization were registered. Age, gender, hospitalization time, oxygen use, SOFA, APACHE II, BRESCIA, PAFI, Leukocytes, creatinine (CrS) andinflammation markers (procalcitonin, ferritin, RCP, LDH, D-dimer) were registered. Results: The incidence of AKI was 40%, 77% were male, 64% had AKI 1 and 36% were AKIN 2 y 3. The use of higher supplemental oxygen, APACHE, BRESCIA, D-Dimer and procalcitonin at day 9 and 12 were associated with AKI. In a logistic regression analysis, risk factor to AKI was septic shock (RR;1.7-117;p=0.013). Other results are shown in Table Conclusions: Inflammatory markers (d-Dimer and procalcitonin) were associated with the development and severity of AKI but only septic shock was predictive of the development of AKI.
ABSTRACT
Since the last months of 2019, SARS-CoV-2 was identified as a highly contagious virus, March 11, 2020 WHO classified SARS-CoV-2 as a pandemic. Since April 21, 2020 Mexican Government declared Phase 3 of his Contingency plan to fight SARS-CoV-2 pandemic. SARS-CoV-2 is mainly a respiratory virus, but there are reports of involvement in organs distant from the lungs, including the kidneys. SARS-CoV-2 kidney involvement is sign of worse prognosis. Is important to know the characteristics of this injury, the way to diagnose it, its treatment and how to prevent it. Here we review some theories about kidney injury related to SARS-CoV-2 infection and its histopathological correlation. We also evaluate the relationship between SARS-CoV-2 and Angiotensin Converting Enzyme 2 receptors, the kidney injury related to the use of the novels therapies against SARS-CoV-2, renal replacement therapies prescription in SARS-CoV-2 y in kidney transplant patients. Since the lasts months SARS-CoV-2 has invaded and modified our knowledge and daily routine. Healthcare staff from the different specialties, including Nephrologist must keep in constant learning and training to fight against this pandemic with the better weapons.